Agenda
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25th Romanian – Hungarian Pediatric Oncology Meeting |
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22-24th November 2024, Sinaia, International Hotel |
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Friday, 22nd |
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15:00-17:30 |
Session I. Challenges and innovations in pediatric hematology-oncology patients – diagnosis and treatment |
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Chairs: Gabor Kovacs, Anca Coliță, Ladislau Ritli |
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15:00 – 15:15 |
Opening speech |
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15:15 – 15:30 |
Brain tumors in children – Institutional epidemiological study – Institute of Oncology “Prof. Dr. Alexandru Trestioreanu” Bucharest 2010-2022 1 Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest |
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15:30 – 15:45 |
A Hungarian initiative for the early identification of hereditary, non-malignant hematopoietic disorders of childhood in the era of molecular medicine B. Egyed 1,2, K. Árvai2, E. Zajta2, L. László Hegyi2, B. Andrássy1,2, Á. Kovács1, A. Bekő2, B. Péterffy2, D. Erdélyi1, J. Müller1, A. Békési1, K. Kállay3, V. Goda3, G. Kriván3, E. Tuboly4, K. Csanádi5, G. Ottóffy6, I. Szegedi7, C. Kiss7, C. Bödör2, D. Alpár2, G. Kovács1 1Semmelweis University Pediatric Center, Budapest 2HAS-SU Momentum Molecular Oncohematology Research Group, Semmelweis University, Department of Pathology and Experimental Cancer Research 3Central Hospital of Southern Pest – National Institute of Hematology and Infectology 4Hungarian Pediatric Oncology Biobank (SCOPEDIS), Hungarian Pediatric Oncology Network 5Heim Pál National Pediatric Institute 6University of Pécs, Department of Pediatrics 7University of Debrecen, Department of Pediatrics |
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15:45 – 16:00 |
Diagnostic challenges in pediatric cancer and leukemia during COVID M. Hegyi Semmelweis University Pediatric Center, Budapest |
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16:00 – 16:15 |
Trying to uncover the mystery: can VUS findings on NGS reveal primary immunodeficiencies in children? A. Șerbănică1,2, A. Marcu1,2, R. Ioan1, A.M. Bică1,2, C. Jercan1,2, L. Radu1,2, A.M. Marcu1,2, R. Obrișcă1,2, P. Lazăr1, E. Bușescu1,2, I. Avrămescu1,2, A. Mocanu1,2, M. Asan 1, A. Gheorghe1, C. Șerban1, C. Popa1,2, C. Jardan1,2, D. Jardan4, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2University of Medicine and Pharmacy “Carol Davila” Bucharest |
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16:15 – 16:30 |
Diagnosis of inherited thrombocytopenia – single center experience R. Obrișcă1,2, A. Marcu1,2, C. Jercan1, A.M. Bică1,2, P. Lazăr1, I. Avrămescu1, R. Ioan1, A. Șerbănică1,2, C. Jardan1,2, D. Jardan4, C. Popa1,2, A. Gheorghe1, L. Radu1,2, A. Ștefan1, A.M. Marcu1, E. Bușescu1,2, A. Mocanu1, A. Coliță2,3, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2University of Medicine and Pharmacy “Carol Davila” Bucharest 3 Colțea Clinical Hospital, Bucharest 4MedLife, Bucharest |
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16:30 – 16.45 |
Insights in molecular classification of ALL – the role of NGS A. Ștefan1,2, L. Radu 1,2, A. Marcu1,2, A.M. Marcu1,2, A. Șerbănică1,2, C. Jercan1,2, A.M. Bică1,2, D. Jardan3, S. Mihai1, S. Alexandru1, I. Avrămescu1,2, E. Bușescu2, A. Mocanu1,2, R. Ioan1, R. Obrișcă1,2, P. Lazăr1, A. Coliță 1,2 1 Fundeni Clinical Institute, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest 3 MedLife, Bucharest |
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16:45 – 17:00 |
TP53 pathogenic mutation in children with myeloid malignancies: a series of cases A. Marcu1,2, A. Șerbanică1,2, C. Jercan1,2, A.M. Bică1,2, L. Radu1,2, A.M. Marcu1, R. Ioan1, P. Lazăr1, R. Obrișcă1,2, I. Avrămescu1, A. Ștefan, E. Bușescu1,2, A. Mocanu1, S. Mihai, D. Jardan3, M. Dragomir1, C. Jardan1,2, C. Popa1,2, A. Gheorghe1, C. Arion2, A. Coliță1,2 1 Fundeni Clinical Institute, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest 3 MedLife, Bucharest |
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17:00 – 17:20 |
Comprehensive genomic testing of pediatric ALL D. Jardan MedLife, Bucharest |
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17:20 – 17.30 |
Discussion |
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17.30 – 18:00 |
Coffee break |
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18:00 - 19:30 |
Session II. Innovative approaches to pediatric stem cell transplantation and cellular therapies |
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Chairs: Peter Lang, Smaranda Arghirescu, Boryana Avramova, Anca Coliță |
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18:00 – 18:15 |
Immune reconstitution following HSCT - Fundeni Clinical Experience I. Avrămescu1,2, R. Obrișcă1,2, A. Ștefan 1,2, P. Lazăr 1, E. Bușescu 1,2, A. Mocanu1,2, C. Jercan1,2, A.M. Bică 1,2, A. Șerbănică1,2, L. Radu1,2, R. Ioan2, A.M. Marcu 1,2, A. Marcu,1,2, C. Popa 1,2, A. Gheorghe1, H. Sandu1, C. Șerban 1,2, A. Coliță1,2 1“Carol Davila” University of Medicine and Pharmacy, Bucharest 2 Fundeni Clinical Institute, Bucharest |
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18:15 – 18:30 |
Hemophagocytic lymphohistiocytosis following CAR-T A.M. Bică1,2, C. Jercan1,2, A. Șerbanică1,2, L. Radu1,2, A. Marcu1,2, C. Popa1,2, M. Asan1, C. Călin1, A. Gheorghe1, C. Șerban1, A. Ichim1, I. Avrămescu1,2, E. Marin1,2, A.M. Marcu1,2, A. Ștefan1,2, R. Obrișcă1,2, R. Ioan1, E. Bușescu1,2, A. Mocanu1,2, D. Tomescu1,2, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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18:30 – 18:45 |
Viral reactivations and delayed immune reconstitution after allogeneic hematopoietic stem cell transplantation in children – whatever comes first C. Jinca1,2, A. Oprișoni1,2, A. Isac2, A. Pașcalău2, L. Balint-Gib2, Ș. Margit2, M. Baica3, S. Arghirescu1,2 1Department of Pediatrics, "Victor Babeș" University of Medicine and Pharmacy, Timișoara 2Emergency Hospital for Children "Louis Țurcanu", Department of Onco-hematology and BMT, Timișoara 3Emergency Hospital for Children "Louis Țurcanu", Lab of Flowcytometry, Timișoara |
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18:45 – 19:00 |
Chronic lymphocytic leukemia in a pediatric patient – case report R. Obrișcă1,2, A. Marcu1,2, C. Jercan1, A.M. Bică1,2, P. Lazăr1, I. Avramescu1, R. Ioan1, A. Șerbănică1,2, C. Jardan1,2, D. Jardan4, C. Popa1,2, A. Gheorghe1, I. Constantinescu1,2, A. Ichim1, L. Radu1,2, A. Ștefan1, A.M. Marcu1, E. Bușescu1,2, A. Mocanu1, A. Coliță2,3, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest 3 Colțea Clinical Hospital, Bucharest 4MedLife, Bucharest |
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19:00 – 19:30 |
NOVARTIS Symposium CAR–T Journey – Fundeni Clinical Institute Experience C. Jercan1,2, A.M. Bică1,2, A. Șerbanică1,2, L. Radu1,2, A. Marcu1,2, C. Popa1,2, M. Asan1, C. Călin1, A. Gheorghe1, C. Șerban1, A. Ichim1, I. Avrămescu1,2, E. Marin1,2, A.M. Marcu1,2, A. Ștefan1,2, R. Obrișcă1,2, R. Ioan1, E. Bușescu1,2, A. Mocanu1,2, D. Tomescu1,2, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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19:30 – 19:45 |
Discussion |
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20:00 |
Dinner |
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Saturday, 23rd |
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09:00 - 11:30 |
Session III. Multimodal strategies in high-risk neuroblastoma |
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Chairs: Peter Lang, Anca Coliță, Codruța Comșa |
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09:00 – 10:00 |
Treatment of relapsed Neuroblastoma with haploidentical stem cell transplantation and immunotherapy P. Lang Department of Pediatrics, Children's University Hospital, University of Tübingen, Tübingen |
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10:00 – 10:15 |
Hematopoietic stem cell transplantation in pediatric patients with neuroblastoma – Fundeni Clinical Experience C. Jercan1,2, A.M. Bică1,2, A. Șerbanică1,2, L. Radu1,2, A. Marcu1,2, M. Asan1, C. Călin1, A. Ichim1, I. Avrămescu1,2, A. M. Marcu1,2, A. Ștefan1,2, R. Obrișcă1,2, R. Ioan1, E. Bușescu1,2, A. Mocanu1,2, C. Jardan 1,2, I. Constantinescu 1,2, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest, România 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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10:15 – 10:30 |
Particular outcomes in neuroblastoma 1Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest |
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10:30 – 10:45 |
Neuroblastoma – past and present experience of IOCN P. Pruteanu, D. Olteanu, M. Cosnarovici, E. Mihuț, R. Popiță, A. Fulop, R. Cosnarovici „Prof. Dr. Ion Chiricuță” Oncology Institute, Cluj-Napoca |
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10:45 – 11:00 |
Dinutuximab: ballancing efficacy and risk A. Ivanov1,2, M. Alecsa1,2, S. Dumitraș2, A. Cianga1,2, I. Miron1,2, C. Comșa3, M. Bădoi3, O. Mihalcea3, S. Drăgușin3, M. Dragomir3,4, P. Pruteanu5, D. Olteanu5, R. Cosnarovici5, C. Jercan4,6, A. M. Bică4,6, A. Șerbanică4,6, I. Avrămescu4,6, A.M. Marcu4,6, A. Ștefan4,6, R. Obrișcă4,6, R. Ioan6, E. Bușescu4,6, A. Mocanu4,6, C. Jardan4,6, L. Radu4,6, A. Marcu4,6, A. Coliță4,6 1“Grigore T. Popa” University of Medicine and Pharmacy, Iași 2„Sf. Maria” Emergency Children Hospital, Iași 3 Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 4“Carol Davila” University of Medicine and Pharmacy, Bucharest 5„Prof. Dr. Ion Chiricuță” Oncology Institute, Cluj-Napoca 6 Fundeni Clinical Institute, Bucharest |
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11:00 – 11:15 |
Targeted therapy in pediatric brain tumors 1Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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11:15 – 11:30 |
Discussion |
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11:30 – 12:00 |
Coffe Break |
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12:00 – 14:30 |
Session IV. Advances in acute leukemia management |
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Chairs: Gabor Kovacs, Cristina Blag, Letiția Radu |
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12:00 – 12:30 |
New possibilities in the treatment of pediatric ALL G. Kovacs, B. Egyed, J. Müller, D. Erdélyi, Cs. Kiss Semmelweis University Pediatric Center, Budapest |
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12:30 – 12:45 |
Treating children with ALL in Fundeni Clinical Institute – Single center experience L. Radu1,2, A.M. Marcu1,2, A.M. Bică1,2, C. Jercan1,2, A. Șerbănică1,2, A. Marcu1,2, R. Ioan1, A. Ștefan1,2, R. Obrișcă1,2, P. Lazăr1, I. Avrămescu1,2, S. Alexandru1, S. Mihai1, A. Moraru1, E. Bușescu1,2, A. Horneț1, M. Marinescu1, T. Iuga-Badea1, L. Dumitrache1, T. Neamțu1, R. Sbora1, M. Dragomir1, O. Călugaru1, C. Jardan1,2, G. Nedelcu1, M. Asan1, C. Călin1, A. Gheorghe1, C. Șerban1, C. Popa1,2, C. Arion2, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest, România 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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12:45 - 13:00 |
Platelet mitochondrial respiration in children with ALL T. Stanciu-Lelcu, M.D. Dănilă, O.M. Aburel, C. Borza, D.M. Muntean ''Victor Babeș'' University of Medicine and Pharmacy - Department of Functional Sciences - Pathophysiology; Centre for Translational Research and Systems |
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13:00 – 13:15 |
Treating ALL first relapses: improving outcomes in Hungary; and the ALL-IC REL T-cell ALL relapse strategy B. Hőbör1, A. Mohás1, V. Enzsöl2, K. Csordás1, K. Csernus3, Zs. Jakab4, D. Erdélyi1, J. Müller1, G. Kovacs1 1Semmelweis University Pediatric Center, Budapest 2Heim Pál National Pediatric Institute, Budapest 3University of Pécs, Department of Paediatrics, Pécs 4National Paediatrics Tumor Register, Budapest |
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13:15 – 13:30 |
Flow-cytometry, a precise technique used to identify and quantify malignant blasts in cerebrospinal fluid (CSF) C. Popa 1,2, A. Gheorghe 1, C. Șerban 1, H. Sandu 1, A. Şerbănică 1,2, C. Jercan 1,2, A.M. Bică1,2, A. Marcu1,2, L. Radu 1,2, A. Coliţă 1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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13:30 – 13:45 |
Therapy related acute myeloid leukaemias – single center experience Department of Pediatric Hematology and Oncology, University Hospital “Tzaritza Joanna”, Sofia |
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13:45 – 14:15 |
AMGEN Educational Session Blincyto in the management of pediatric ALL A.M. Bică1,2, C. Jercan1,2, A. Șerbanică1,2, L. Radu1,2, A. Marcu1,2, C. Popa1,2, M. Asan1, C. Călin1, A. Gheorghe1, C. Șerban1, I. Avrămescu1,2, R. Obrișcă1,2, R. Ioan1, E. Bușescu1,2, A. Mocanu1,2 A.M. Marcu1,2, A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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14:15 – 14:30 |
Discussion |
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14:30 – 15:30 |
Lunch |
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15:30 – 17:00 |
Session V. Pediatric Cancer Data Systems |
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Chairs: Kathy Pritchard-Jones, Mihaela Bucurenci, Alina Pătrăhău |
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15:30 – 15:40 |
Trends in Pediatric Cancer Survival in Romania – highlights of the National Pediatric Cancer Registry Report M. Bucurenci1, A. Neaga1, D. Coza2 1 The National Register of Pediatric Onco-Hematology 2North-west Regional Cancer Registry |
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15:40 – 15:50 |
15 years of Pediatric Cancer Registration in Romania – challenges and perspectives M. Bucurenci1, A. Neaga1, A. Topor2 1 The National Register of Pediatric Onco-Hematology 2 Dăruiește Aripi Asssociation |
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15:50 – 16:00 |
DARA - A Customized Data System Supporting Integrated Care for Pediatric Cancer Patients A. Pătrăhau2, A. Topor2, M. Bucurenci1 1 The National Register of Pediatric Onco-Hematology 2 Dăruiește Aripi Asssociation |
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16:00 – 16:15 |
International Benchmarking of childhood cancer survival by stage at diagnosis - results of the BENCHISTA project G. Gatta Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Lombardia |
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16:15 – 16:30 |
Tumour-specific analyses planned for BENCHISTA phase II and invitation to join the project K. Pritchard-Jones Paediatric Oncology at University College London (UCL) Great Ormond Street Institute of Child Health, London |
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16:30 – 16:45 |
The Establishment and Current Operation of the Hungarian Pediatric Registry M. Garami1, Zs. Jakab2 1Second Department of Pediatrics, Semmelweis University, Budapest 2National Paediatrics Tumor Register, Budapest |
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16:45 – 17:00 |
Discussion |
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17:30 |
Social program |
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Sunday, 24th |
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09:00 - 11:15 |
Session VI. Advances and unresolved challenges in pediatric patients with hematology-oncology diseases: Varia Session |
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Chairs: Milica Stefanovic, Gabor Benyo, Monica Dragomir |
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09:00 – 09:15 |
Renal complications in children with β-thalassemia S. Simeonova, A. Bantchev, B. Avramova Department of Pediatric Hematology and Oncology, University Hospital "Tzaritza Joanna", Sofia, Bulgaria |
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09:15 – 09:30 |
Pain and pain relief Gábor Benyo1,2 1Tábitha Children's Hospice House 2Semmelweis University, Paediatric Clinic, Budapest |
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09:30 – 09:45 |
FORTEe Clinical Trial Implements Pediatric Oncology Exercise at Ljubljana Children's Hospital, Slovenia M. Stefanovic1, M. A. Neu2, E. Dreismickenbecker2, F. Lanfranconi3, A. Balduzzi3, C. Fiuza-Luces4, A. Lucia5, M. K. Fridh6, H. Marriott7, E. Watson7, J. Wiskemann8, N. Bauer8, M. Götte9, R. Mongondry10, B. Konda11, F. Spreafico12, J. Faber2 on behalf of the FORTEe Consortium 1 University Medical Center Ljubljana 2 University Medical Center of the Johannes Gutenberg-University Mainz, Childhood Cancer Center 3 Fondazione Monza e Brianza per Il Bambino e La Sua Mamma 4 Hospital 12 de Octubre Research Institute, Madrid 5 Universidad Europea de Madrid 6 University Hospital Rigshospitalet, Copenhagen 7 Oxford Brookes University 8 Heidelberg University Hospital and National Center for Tumor Diseases 9 Essen University Hospital 10 Centre de Lutte Contre le Cancer Léon Bérard, Lyon 11 Forma 3D Ltd., Ljubljana 12 Fondazione IRCCS Istituto Nazionale dei Tumori, Milan |
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09:45 – 10:00 |
Understanding Vincristine-induced neuropathy (VIN): prevalence and predisposing factors D. Koch1,2, G. Kovacs2 1Centre for Translational Medicine, Semmelweis University, Budapest 2Pediatric Center, Semmelweis University, Budapest |
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10:00 – 10:15 |
In the middle of the cytokine storm – hemophagocytic lymphohistiocytosis in children M. Bota1,2, M. Colceriu1, C. Blag1,2 1Emergency Clinical Hospital for Children, Second Pediatric Clinic Cluj-Napoca 2”Iuliu Hațieganu” University of Medicine and Pharmacy, Cluj-Napoca |
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10:15 – 10:30 |
The use of autologous stem cell transplantation in patients with Ewing Sarcoma – single center experience O. Velikonja Pediatric clinic, UKC Ljubljana |
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10:30 – 10:45 |
Malignant peripheral nerve sheath tumour in a patient with neurofibromatosis type 1 N. Salobir, O. Velikonja Pediatric clinic, UKC Ljubljana |
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10:45 – 11:00 |
Discussion |
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11:00 – 11:30 |
Coffee break |
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11:30 – 13:15 |
Session VII. Comprehensive approach to pediatric patients with onco-hematological diseases |
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Chair: Orjana Velikonja, Adrienne Horvath, Andreea Șerbănică |
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11:30 – 11:45 |
Interstitial brachytherapy for bladder–prostate rhabdomyosarcoma in children 1Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest |
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11:45 – 12:00 |
Chemotherapy-induced SIADH: a rare complication in solid tumor management 1Institute of Oncology „Prof. Dr. Al. Trestioreanu”, Bucharest 2 “Carol Davila” University of Medicine and Pharmacy, Bucharest |
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12:00 – 12:30 |
Nestle symposium Nutrition – from support to treatment in pediatric patients with onco-hematological diseases A. Coliță1,2 1Fundeni Clinical Institute, Bucharest 2“Carol Davila” University of Medicine and Pharmacy, Bucharest |
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12:30 – 12:45 |
The mission and role of APCAO Association in the care of children with oncological conditions A. Năstase APCAO Association |
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12:45 – 13:00 |
The physiotherapist's contribution to the multidisciplinary approach team for pediatric patients with ALL C. Fărcășanu APCAO Association |
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13:00 – 13:15 |
The need for complementary social services in the treatment of children with cancer A. Brinzoiu, A. Nechita MagiCAMP Asssociation |
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13:15 – 13:30 |
Discussion |
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13:30 – 13:45 |
Closing remarks |
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14:00 |
Lunch |